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Echinacea Premium combines the roots of Echinacea angustifolia and Echinacea purpurea to enlist properties unique to each. The blending of these two plant species ensures that the specific caffeic acid derivatives (cichoric acid, echinacoside, cynarin) and the lipophilic components (especially alkylamides) are present in appropriate quantities. This product contains a total of 4.1 mg of alkylamides per tablet to ensure optimal strength and quality. These substances and other unnamed phytochemicals work together to:
Echinacea Research Handout
Suggested Use:1 tablet 2 - 3 times daily, or as directed.
In November 2014, independent tests of nine U.S. Echinacea tablet and capsule products showed that MediHerb Echinacea Premium tablets are higher in alkylamides (both 2-ene and 2,4-diene alkylamides), which are clinically proven active constituents. The testing was conducted by an independent analytical laboratory accredited by the Australian Therapeutic Goods Administration.
2-ene are only found in Echinacea angustifolia and are an important measure of quality. MediHerb’s research has found that 2-ene alkylamides improve the bioavailability of 2,4-diene alkylamides in Echinacea purpurea.
This means that the alkylamides in MediHerb’s unique blend, Echinacea Premium, are available to the body, resulting in a better effect on the immune system. MediHerb’s Echinacea Premium formula is patented in Australia, New Zealand and the U.K. with a patent applied for in the U.S. to protect this important finding.
MediHerb Echinacea products are labeled with their alkylamide content (both 2-ene and 2,4-diene alkylamides). The testing below reports the alkylamide content of MediHerb Echinacea Premium and nine other U.S. Echinacea products. Note that most of the other Echinacea products do not make claims of alkylamide content. Through research, MediHerb has determined alkylamides are important constituents of Echinacea.
Echinacea is the most widely used herb and the most misunderstood. MediHerb has for many years invested heavily into research on Echinacea to identify quality markers that are important for therapeutic use. The levels of the phenolic acid esters, e.g. echinacoside, are commonly used by many manufacturers as marker compounds or indicators of Echinacea quality. However, recent trials have highlighted the significance of alkylamides for clinical efficacy, hence it is important that quality products are characterized for these phytochemicals as well. This has led to the incorporation of a specification and analytical test methodology for Echinacea products in the USP26-NF21 draft monographs which focuses on alkylamides tested by HPLC and DAD detection. The alkylamides being tested are the 2,4-diene alkylamides and the 2-ene alkylamides.
This method has been adopted by MediHerb and the alkylamides are determined as 2,4-diene alkylamides and 2-ene alkylamides. The 2-enes are characteristic of Echinacea angustifolia and are not found in the other species. The 2,4-dienes are found in both E. purpurea and E. angustifolia and these phytochemicals are responsible for the intense tingling sensation in the mouth when tasting good quality Echinacea products.
The phenolic acids are determined as the levels of caftaric acid, echinacoside and cichoric acid; echinacoside is typical of E. angustifolia and E. pallida roots and is not found in E. purpurea. Cichoric acid is not found in E. angustifolia root, but is found in the aerial parts of all species and characteristically in the root of E. purpurea.
MediHerb products are quantified to contain a minimum level of alkylamides by the USP26-NF21 HPLC method, the levels of phenolic acids are measured for information only and are used to confirm product identity and the absence of contamination from other Echinacea species.
MediHerb has developed specialized knowledge in the manufacture and testing of Echinacea products over the past 20 years. This includes a PhD study, extensive analytical method development, establishment of optimal harvesting, drying and storage protocols to maximize retention of actives and a successful clinical trial.
Caution: Contraindicated in known allergy to plants of the daisy family. Not to be used during pregnancy and lactation unless otherwise directed by a qualified health care professional.
†Daily Value (DV) not established.
For other contraindications and cautions specific to this product, please refer to the Contraindications and Cautions for MediHerb Botanicals.
Please consult the product packaging label for the most accurate product information.
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