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  • Gluten Free

Introduced in 1963

Product # Content Price
5680 90 Capsules $25.50
5700 150 Capsules $39.00

Multizyme contains digestive enzymes to support the proper breakdown of proteins, carbohydrates, and fats.*

  • Contains enzymes to provide support in the gastric and intestinal phases of digestion
  • Supports pancreatic function with supplemental pancreatic enzymes*
How do enzymes support digestion?

Enzymes are proteins made by the body that facilitate chemical reactions, e.g., enzymes produced by the gut to aid digestion.1 Enzymes are needed to digest food; produce energy inside cells; activate the brain; help the body maintain the function of cells, tissues, and organs; and support other functions of the body. Without enzymes, many chemical reactions in the body would not be supported.

The substances on which enzymes act are called substrates, and enzymes may be very specific for particular substrates and/or may only catalyze a particular transformation of a substrate.2

Enzymes fall into two main categories: digestive or metabolic. Digestive enzymes work in the intestinal tract to break down the foods we eat so nutrients can be absorbed into the blood for use in the body. Categories of digestive enzymes include amylases, proteases, and lipases. Amylases, which are produced in human saliva and pancreas secretions, break down starch, a main source of carbohydrates in the human diet.3 Proteases (enzymes that break down proteins) cleave the bond between amino acids, which are the building blocks of all proteins.4 Proteases found in the digestive tract include gastric pepsins,5 the serine proteases6 trypsin and chymotrypsin, and carboxypeptidases.7, 8, 9, 10 Lipases are enzymes that digest fats and are found in the stomach and pancreatic secretions.11, 12

Additionally, some plant- and animal-based proteolytic enzymes can be obtained from food. Raw foods from both plant and animal sources can be a beneficial source of enzymes, since heat and cooking methods can destroy these sensitive molecules. Digestive enzymes enable our bodies to obtain optimal nutritional benefit from the foods we eat.*

How do the enzymes in Multizyme support the efficient breakdown of foods and absorption of nutrients?

Pancreatin is a mixture of pancreatic enzymes, including lipases, amylases, and proteases.13 This enzyme mix breaks down dietary proteins into peptides and amino acids, fats (lipids) into fatty acids, and starch into simple sugars. Bromelain14 and papain,15 an endolytic plant cysteine protease enzyme found in papaya as well as many other organisms, are proteolytic enzymes that digest proteins. Lipases break down lipid molecules (fats) found in foods.16 Cellulases break down cellulose, one of the three main components of plant lignocellulose, into sugar molecules.17 Amylases break down starch.18 Together, enzymes in Multizyme work synergistically to encourage the efficient breakdown of food in the digestive tract and enhance the absorption of vital nutrients.*

  • 1. PubMed Health. Accessed November 25, 2015.
  • 2. Suzuki, H. 2015. How Enzymes Work: From Structure to Function. CRC Press, Boca Raton, Florida, p. 2.
  • 3. Butterworth PJ, Warren FJ, Ellis PR. 2011. Human alpha-amylase and starch digestion: An interesting marriage. Starch/Stärke. 63:395-405.
  • 4. Lopez-Otin C, Bond JS. 2008. Proteases: Multifunctional Enzymes in Life and Disease. J Biol. Chem. 283:30433-30437.
  • 5. See note 4 above.
  • 6. Antalis GM, Bugge T, Wu Q. 2011. Membrane-anchored serine proteases in health and disease. Prog Mol Biol Transl Sci. 99:1-50.
  • 7. Pandol SJ. 2015. Normal Pancreatic Function. Pancreapedia DOI: 10.3998/panc.2015.17
  • 8. Doyle CJ, Yancey K, Pitt HA, Wang M, Bemis K, Yip-Schneider MT, Sherman S, Lillemoe KD, Goggins MD, Schmidt C2012. M. The Proteome of Normal Pancreatic Juice. 41(2):186–194.
  • 9. Medeiros DM, Wildman REC. 2015. Advanced Human Nutrition. Jones & Bartlett Learning, Burlington, MA, p.150-151.
  • 10. Whitcomb DC, Lowe ME. 2007. Human pancreatic digestive enzymes. Dig Dis Sci. 52(1):1-17.
  • 11. Winkler FK, D’Arcy A, Hunziker W. 1990. Structure of human pancreatic lipase. Nature 343:771-774.
  • 12. Armand M. 2007. Lipases and lipolysis in the human digestive tract: where do we stand? Curr Opin Clin Nutr Metab Care. 10(2):156-64.
  • 13. Ferrone M, Raimondo M, Scolapio JS. 2007. Pancreatic enzyme pharmacotherapy. Pharmacotherapy 27:910–920.
  • 14. Pavan R, Jain S, Shraddha, Kumar A. 2012. Properties and Therapeutic Application of Bromelain: A Review. Biotechnol Res Int. 2012: 976203.
  • 15. Amri E, Mamboya F. 2012. Papain, a plant enzyme of biological importance: A review. Am J Biochem Biotechnol. 8:99-104.
  • 16. Hasan F, Shah AA, Hameed A. 2009. Methods for detection and characterization of lipases: A comprehensive review. Biotechnol Adv. 27:782-798.
  • 17. Lambertz C, Garvey M, Klinger J, Heesel D, Klose H, Fischer R, Commandeur U. 2014. Challenges and advances in the heterologous expression of cellulolytic enzymes: a review. Biotechnol Biofuels. 7(1):135.
  • 18. See note 3 above.

Synergistic Product Support

Whole Food Nutrient Solutions

Since 1929, Standard Process has been the visionary leader in whole food nutrient solutions. We apply systems thinking to holistic nutrition that empowers practitioners to transform lives. Dedicated to the whole food philosophy of our founder, Dr. Royal Lee, our goal is to carry on his mission to provide nutrients for the body that are as close as possible to how they are found in nature.

Our products include foods that are prepared in a way that safeguards their nutritional value. The majority of these ingredients are grown locally on our certified organic farm and may require chopping, dicing, juicing, and/or drying for use in our products. The resulting whole food ingredients are then added to a formula that may include whole food extracts, animal tissue extracts and concentrates, botanicals, whole food isolates, and synthetic ingredients. These highly complex combinations contain a variety of elements designed to trigger trophic effects that support the body’s healthy balance and wellness.*


Suggested Use: One capsule per meal, or as directed.

Supplement Facts
Serving Size: 1 Capsule Servings per Container: 90 or 150
Amount per Serving %Daily Value
Calories 2  
Cholesterol 5 mg 2%
Proprietary Blend: 410 mg Fig (fruit)†, defatted almonds†, pancreatin (3x)†, stearic acid (vegetable source)†, bromelain†, lipase†, cellulase†, papain†, and amylase†.

†Daily Value not established.

Other Ingredients: Gelatin, lactose (milk), maltodextrin, water, and calcium stearate.

Please consult the actual product label for the most accurate product information.

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.