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ProSynbiotic Fundamentals Product

  • Gluten Free

Introduced in 2010

Product # Content Price
7080 90 Capsules $39.00

ProSynbiotic is a synergistic blend of four research-supported probiotic strains and two prebiotic fibers to support gut flora and overall intestinal health

  • Contains research-supported strains of lactic acid bacteria (Lactobacillus and Bifidobacterium), and Saccharomyces cerevisiae var. boulardii
  • Contains inulin, a nondigestible soluble fiber from chicory root, and galactooligosaccharide (GOS), a nondigestible carbohydrate, both of which are used by probiotic bacteria as food
  • Useful in maintaining a healthy gut microbial environment
  • Helps support the body's natural absorption of calcium and magnesium
  • Improves nutrient digestion and absorption
  • Supports normal bowel regularity and consistency
  • Supports the body's natural immune system function*
ProSynbiotic contains clinically documented strains that work synergistically with prebiotic fibers.

Lactobacillus acidophilus (including LA-5®)—The LA-5 strain has been evaluated for its ability to interfere with the communication between other types of bacteria, thus promoting a healthy balance of microbes. The LA-5 strain was also among several other lactobacilli that improved outcomes in subjects with occasional constipation, as well as those with lactose tolerance challenges.*

Lactobacillus paracaseissp. paracasei (L.casei 431®)—To support the natural gut environment, this strain of lactic acid­producing bacteria adheres to the intestinal tract and tolerates bile. This strain has been studied in humans and mice for its ability to support the gut during challenges and for its ability to help maintain the body's natural immune system response.*

Bifidobacterium lactis (BB-12®)—Bifidobacteria are very tolerant of both acidic conditions and environments that contain bile. Bifidobacteria use a range of carbohydrates for energy (including GOS). Bifidobacteria are an important factor in all native microflora and their numbers vary depending on lifestyle, diet, exercise and age. Oral bifidobacteria have been shown to temporarily colonize the gut, competing with other bacteria to effectively support the natural bacterial balance.*

Saccharomyces cerevisiae var. boulardii—Historically, this microbe was used to support normal stool consistency. In the gut, this yeast supports the growth of some bacteria and inhibits others through competition and environmental modification of the gut.*

Inulin—Inulin is a complex carbohydrate that can be digested by certain microorganisms, providing them with energy. Inulin supports the absorption of calcium and magnesium.*

Galactooligosaccharide (GOS)—Research suggests that GOS is a preferred substrate for BB-12. In mice, GOS supplementation supported the active proteins and cells in the gut mucosa, and increased the amount of short-chain fatty acid and lactate in the gut.*

LA-5®, BB-12®, and L. casei 431® are registered trademarks of Chr. Hansen, Inc.

Gluten FreeThis product contains less than 20 parts per million per the suggested use listed on each product label.

Please consult the actual product label for the most accurate product information.

Synergistic Product Support


Show Studies 

Studies on nutrients generally use large doses and these studies, some of which are cited below, are the basis for much of the information we provide you in this publication about whole food ingredients. See the supplement facts for ProSynbiotic.

  1. Barbosa T, Rescigno M. 2010. WIREs Systems Biology and Medicine. 2(1):80-97.
  2. Battacock M, Azam-Ali S. FAO Agricultural Services Bulletin - 134: Fermented fruits and vegetables. A global perspective... 1998; View Study. Accessed May 13, 2010.
  3. Collado MC, Grzeskowiak L, Salminen S. 2007. Curr Microbiol. 55(3):260-265.
  4. Cummings JH, Macfarlane GT, Englyst HN. 2001. Prebiotic digestion and fermentation. Am J Clin Nutr. 73(2 Suppl):415S-420S.
  5. Davidson A. 2006. The Oxford Companion to Food. New York: Oxford University Press.
  6. de LeBlanc Ade M, Castillo NA, Perdigon G. 2010. Int J Food Microbiol. 138(3):223-231.
  7. Dogi CA, Galdeano CM, Perdigon G. 2008. Gut immune stimulation by non-pathogenic Gram(+) and Gram(-) bacteria. Comparison with a probiotic strain. Cytokine. 41(3):223-231.
  8. FAO/WHO. Food and Agriculture Organization of the United Nations/ World Health Organization Working Group for the Evaluation of Probiotics in Food: Guidelines for the Evaluation of probiotics in food. 2002; View Study. Accessed May 13, 2010.
  9. Fuller R. 1991. Probiotics in human medicine. Gut. 32(4):439-442.
  10. Gibson GR, Beatty ER, Wang X, Cummings JH. 1995. Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology. 108(4):975-982.
  11. Gibson GR, Wang X. 1994. Enrichment of bifidobacteria from human gut contents by oligofructose using continuous culture. FEMS Microbiol Lett. 118(1-2):121-127.
  12. Gibson GR, Wang X. 1994. Regulatory effects of bifidobacteria on the growth of other colonic bacteria. J Appl Bacteriol. 77(4):412-420.
  13. Gill SR, Pop M, Deboy RT, et al. 2006. Metagenomic analysis of the human distal gut microbiome. Science. 312(5778):1355-1359.
  14. Gorbach SL. Microbiology of the Gastrointestinal Tract. In: Baron S, ed. Medical Microbiology, 4th Ed. Galveston: The University of Texas Medical Branch at Galveston, TX; 1996.
  15. Helland MH, Wicklund T, Narvhus JA. 2004. Growth and metabolism of selected strains of probiotic bacteria, in maize porridge with added malted barley. Int J Food Microbiol. 91(3):305-313.
  16. Kanauchi O, Mitsuyama K, Araki Y, Andoh A. 2003. Curr Pharm Des. 9(4):333-346.
  17. Langlands SJ, Hopkins MJ, Coleman N, Cummings JH. 2004. Prebiotic carbohydrates modify the mucosa associated microflora of the human large bowel. Gut. 53(11):1610-1616.
  18. Leforestier G, Blais A, Blachier F, et al. 2009. Effects of galacto-oligosaccharide ingestion on the mucosa-associated mucins and sucrase activity in the small intestine of mice. Eur J Nutr. 48(8):457-464.
  19. Medellin-Pena MJ, Wang H, Johnson R, Anand S, Griffiths MW. 2007. Appl Environ Microbiol. 73(13):4259-4267.
  20. Mueller S, Saunier K, Hanisch C, et al. 2006. Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study. Appl Environ Microbiol. 72(2):1027-1033.
  21. Okada M, Bothin C, Kanazawa K, Midtvedt T. 1999. Br J Surg. 86(7):961-965.
  22. Pan XD, Chen FQ, Wu TX, Tang HG, Zhao ZY. 2009. Prebiotic oligosaccharides change the concentrations of short-chain fatty acids and the microbial population of mouse bowel. J Zhejiang Univ Sci B. 10(4):258-263.
  23. Qin J, Li R, Raes J, et al. 2010. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 464(7285):59-65.
  24. Roberfroid MB, Bornet F, Bouley C, Cummings JH. 195. Colonic microflora: nutrition and health. Summary and conclusions of an International Life Sciences Institute (ILSI) [Europe] workshop held in Barcelona, Spain. Nutr Rev. 53(5):127-130.
  25. Sartor RB. 2008. Gastroenterology. 134(2):577-594.
  26. Scholz-Ahrens KE, Ade P, Marten B, et al. 2007. Prebiotics, probiotics, and synbiotics affect mineral absorption, bone mineral content, and bone structure. J Nutr. 137(3 Suppl 2):838S-846S.
  27. Sherman PM, Ossa JC, Johnson-Henry K. 2009. Unraveling mechanisms of action of probiotics. Nutr Clin Pract. 24(1):10-14.
  28. Tabasco R, Garcia-Cayuela T, Pelaez C, Requena T. 2009. Lactobacillus acidophilus La-5 increases lactacin B production when it senses live target bacteria. Int J Food Microbiol. 132(2-3):109-116.
  29. Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. 2006. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 444(7122):1027-1031.
  30. Vernazza CL, Gibson GR, Rastall RA. 2006. Carbohydrate preference, acid tolerance and bile tolerance in five strains of Bifidobacterium. J Appl Microbiol. 100(4):846-853.
  31. Vulevic J, Drakoularakou A, Yaqoob P, Tzortzis G, Gibson GR. 2008. Modulation of the fecal microflora profile and immune function by a novel transgalactooligosaccharide mixture (B-GOS) in healthy elderly volunteers. Am J Clin Nutr. 88(5):1438-1446.
  32. Wall R, Hussey SG, Ryan CA, et al. 2008. Presence of two Lactobacillus and Bifidobacterium probiotic strains in the neonatal ileum. ISME J. 2(1):83-91

Whole Food Nutrient Solutions

Since 1929, Standard Process has been the visionary leader in whole food nutrient solutions. We apply systems thinking to holistic nutrition that empowers practitioners to transform lives. Dedicated to the whole food philosophy of our founder, Dr. Royal Lee, our goal is to carry on his mission to provide nutrients for the body that are as close as possible to how they are found in nature.

Our products include foods that are prepared in a way that safeguards their nutritional value. The majority of these ingredients are grown locally on our certified organic farm and may require chopping, dicing, juicing, and/or drying for use in our products. The resulting whole food ingredients are then added to a formula that may include whole food extracts, animal tissue extracts and concentrates, botanicals, whole food isolates, and synthetic ingredients. These highly complex combinations contain a variety of elements designed to trigger trophic effects that support the body’s healthy balance and wellness.*


Suggested Use: Three capsules per day, or as directed.

Special Information: Store in a cool, dry place. Although research varies, our strains seem to work best when taken after a meal.

Supplement Facts
Serving Size: 3 Capsules Servings per Container: 30
Amount per Serving %DV
Calories 8  
Total Carbohydrate 1.8 g <1%*

Proprietary Blend: 1,700 mg Inulin, galactooligosaccharide (GOS) (milk), and probiotic blend (S. boulardii, L. acidophilus, LA-5®, L. paracasei, L.casei 431®, and Bifidobacterium, BB-12®) (4 billion cfu).

*Percent Daily Values (DV) are based on a 2,000 calorie diet.

†Daily Value (DV) not established.

Other Ingredients: Maltodextrin, gelatin, water, calcium stearate, and sorbitan monostearate.

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.