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Ligaplex® II

Introduced in 1961

Product # Content Price
5300 150 Capsules $30.00

Ligaplex II supports tissue and joints to maintain connective tissue health, especially for long-term support.*

How does Ligaplex II help maintain a healthy skeletal system?

Ligaplex II contains bone-supporting whole food ingredients like bovine bone and veal bone. Bovine bone and veal bone PMG™ extract are used to support healthy connective tissue. A study showed that treating bone cells (mouse pre-osteoblast cells) grown under laboratory conditions with bovine bone supplements resulted in increased proliferation of bone-forming cells (osteoblasts) and accumulation of hardened (mineralized) bone material. 1*

Bone tissue serves as a reservoir of calcium and helps the body maintain a constant level of Ca+2 ions.2 It is important to understand that calcium is required throughout the human life cycle, a proper supply is required for overall health, calcium requirements change over time, and calcium inadequacies at various stages in life may result in a loss of bone density.3 Vitamin D is required by the body to absorb and mobilize calcium and also assists in natural immune modulation in the body.4 An important function of vitamin A is cellular differentiation and tissue repair.5 Manganese plays a role in stimulating the creation of new bone material and calcification of bones, helps adults maintain a healthy skeleton,6 and facilitates the formation of connective tissue in the body.7 Some cellular processes, such as lipid, carbohydrate, and protein metabolism, are dependent on manganese; manganese is used by many enzymes in the body.8 Vitamin C is essential for collagen synthesis9 and collagen matrix quality.10*

How does this product support healthy fluid levels?

In the body, carbamide (urea) plays a key role in the concentration of urine. Along with sodium chloride, urea helps support healthy concentration of urine.11 The maintenance of proper fluid levels in the tissues surrounding joints helps keep them healthy.12*

How does bovine heart PMG™ extract support healthy tissues?

Bovine heart PMG™ extract is a complex raw material. This ingredient distills the complexity of the heart tissue to support human heart muscle function.*

  • 1. Liu J, Zhang B, Song S, Ma M, Si S, Wang Y, Xu B, Feng K, Wu J, Guo Y. 2014. Bovine Collagen Peptides Compounds Promote the Proliferation and Differentiation of MC3T3-E1 Pre-Osteoblasts. PLoS ONE. 9:6 e99920.
  • 2. Boskey A.L., Coleman R. 2010. Aging and Bone. J Dent Res. 89(12):1333–1348.
  • 3. Beto J.A. 2015. The Role of Calcium in Human Aging. Clin Nutr Res. 4(1):1-8.
  • 4. Hossein-nezhad A and Holick MF. 2013. Vitamin D for Health: A Global Perspective. Mayo Clin Proc. 88(7): 720-755.
  • 5. Modern Nutrition in Health and Disease editors A Catharine Ross, et al. Wolters Kluwer, Lippincott Williams & Wilkins, Baltimore, MD. 2014. Pp 260-277.
  • 6. Zofková I., Nemcikova P., Matucha P. 2013. Trace elements and bone health. Clin Chem Lab Med. 51(8):1555-61.
  • 7. Ehrlich SD. 2011. Manganese. University of Maryland Medical Center.
  • 8. Kehl-Fie T.E., Skaar E.P. 2010. Nutritional immunity beyond iron: a role for manganese and zinc. Curr Opin Chem Biol 14:218-224.
  • 9. Traber, M. G., & Stevens, J. F. (2011). Vitamins C and E: Beneficial effects from a mechanistic perspective. Free Radical Biology & Medicine, 51(5), 1000–1013.
  • 10. Aghajanian, P., Hall, S., Wongworawat, M. D. and Mohan, S. (2015), The Roles and Mechanisms of Actions of Vitamin C in Bone: New Developments. J Bone Miner Res, 30: 1945–1955. doi:10.1002/jbmr.2709
  • 11. Sands JM, Layton HE. 2009. The Physiology of Urinary Concentration: an Update. Semin Nephrol. 29(3): 178–195.
  • 12. Daniel, M. Wien Med Wochenschr (2014) 164: 88. doi:10.1007/s10354-013-0240-2
  • 13. Aghajanian, P., Hall, S., Wongworawat, M. D. and Mohan, S. (2015), The Roles and Mechanisms of Actions of Vitamin C in Bone: New Developments. J Bone Miner Res, 30: 1945–1955. doi:10.1002/jbmr.2709

Whole Food Nutrient Solutions

Since 1929, Standard Process has been the visionary leader in whole food nutrient solutions. We apply systems thinking to holistic nutrition that empowers practitioners to transform lives. Dedicated to the whole food philosophy of our founder, Dr. Royal Lee, our goal is to carry on his mission to provide nutrients for the body that are as close as possible to how they are found in nature.

Our products include foods that are prepared in a way that safeguards their nutritional value. The majority of these ingredients are grown locally on our certified organic farm and may require chopping, dicing, juicing, and/or drying for use in our products. The resulting whole food ingredients are then added to a formula that may include whole food extracts, animal tissue extracts and concentrates, botanicals, whole food isolates, and synthetic ingredients. These highly complex combinations contain a variety of elements designed to trigger trophic effects that support the body’s healthy balance and wellness.*


Suggested Use: Two capsules per meal, or as directed.

Supplement Facts
Serving Size: 2 Capsules Servings per Container: 75
Amount per Serving %DV
Calories 4  
Total Carbohydrate 1 g <1%*
Vitamin A 585 IU 10%
Vitamin C 1.3 mg 2%
Vitamin D 25 IU 6%
Vitamin E 1 IU 4%
Vitamin B12 2 mcg 35%
Calcium 22.4 mg 2%
Manganese 35 mg 1,750%
Proprietary Blend: 660 mg Nutritional yeast†, carbamide†, bovine bone†,veal bone PMG™ extract†, bovine liver†, defatted wheat(germ)†, bovine heart PMG™ extract†, magnesium citrate, oat flour†,inositol†, dried pea(vine) juice†, Tillandsia usneoides†, carrot(root)†, sweet potato†, ribonucleic acid†, beet(root)†, bovine liver fat extract†, bovine spleen†, ovine spleen†, bovine adrenal Cytosol™ extract† bovine kidney†, mushroom†, para-aminobenzoate†,rice(bran)†, sunflower lecithin†, and flaxseed oil extract†.
*Percent Daily Values (DV) based on a 2,000 calorie diet.

†Daily Value (DV) not established.

Other Ingredients: Manganese glycerophosphate, gelatin, calcium lactate, calcium stearate, ascorbic acid, vitamin A palmitate, d-alpha tocopherol (vitamin E sunflower), cyanocobalamin, and cholecalciferol.

Please consult the actual product label for the most accurate product information.

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.