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Kava Forte

Fundamentals Product

This tablet contains Kava root extracted with 100% water, which provides an extract with a full spectrum of compounds including the kavalactones. This product is standardized to contain 50 mg of kavalactones per tablet to ensure optimal strength and quality.The compounds in Kava Forte, particularly the kavalactones, work together to:

  • calm the nerves
  • ease the effects of everyday tension and stress
  • promote relaxation and sleep
  • support the relief of muscular tension Δ
  • Vegetarian
  • Content Product #
    40 Tablets M1345

Suggested Use: 1 tablet 2 – 3 times daily, or as directed.

Serving Size: 1 Tablet

Supplement Facts

Amount Per Serving   %DV
† Daily Value (DV) not established.
Calories 4  
Kava root 7:1 water extract
from Piper methysticum root 3.2 g
Containing kavalactones 50 mg
455 mg

Other Ingredients

Water, cellulose, hypromellose, maltodextrin, silicon dioxide, sodium starch glycollate, magnesium stearate and calcium acid phosphate.

Caution: US FDA advises that a potential risk of rare, but severe, liver injury may be associated with kava-containing dietary supplements. Ask a health care professional before use if you have or have had liver problems, frequently use alcoholic beverages, or are taking any medication. Stop use and see a doctor if you develop symptoms that may signal liver problems (eg unexplained fatigue, abdominal pain, loss of appetite, fever, vomiting, dark urine, pale stools, yellow eyes or skin). Not for use by persons under 18 years of age, or by pregnant or breastfeeding women. Not for use with alcoholic beverages. Excessive use, or use with products that cause drowsiness, may impair your ability to operate a vehicle or dangerous equipment. Not for prolonged use. Do not exceed recommended dose. For other contraindications and cautions consult your health care professional.

For other contraindications and cautions specific to this product, please refer to the Contraindications and Cautions for MediHerb Botanicals.

Why Use MediHerb's Kava Forte?

  • Water Extracted: Kava Forte respects the traditional preparation and usage of Kava. It is made from 100% water extraction
  • Safety: The safety of water extract of Kava has been evaluated in a number of studies1-4
  • Noble Cultivars: MediHerb uses only the noble cultivars of Kava – the prized varieties chosen by traditional producers of Kava
  • Research Investment:
    • The traditional Kava preparation and usage is validated by research. MediHerb is the only company to invest in research of aqueous extracted Kava
    • MediHerb supplied Kava tablets for numerous positive clinical trials and continues to work with researchers to better understand the therapeutic activity of Kava5-8
    • MediHerb invested in analytical research to understand the in vitro bioavailability of water versus ethanol extracts of Kava. This research has been published in a peer-reviewed scientific journal, so health care professionals could have peace of mind in prescribing the new water based extract9

MediHerb has a long history with Kava research and clinical use. Kava is one of the favorite herbs of Professor Kerry Bone, MediHerb Co-Founder and Director of Research and Development.

References

  1. Singh YN, Devkota AK. Planta Med 2003; 69(6): 496-499
  2. Teschke R, Sarris J, Glass X, Schulze J. Br J Clin Pharmacol 2011; 71(3): 445-448
  3. Teschke R. Liver Int 2010; 30(9): 1270-1279
  4. Sarris J, Stough C, Teschke R et al. Phytother Res 2013; [Epub ahead of print]
  5. Sarris J, Stough C, Bousman CA et al. J Clin Psychopharmacol In Press
  6. Sarris J, Kavanagh DJ, Byrne G et al. Psychopharmacology 2009; 205(3): 399-407
  7. Sarris J, Adams J, Kavanagh DJ. Aust J Med Herb 2010; 22(1): 12-16
  8. Sarris J, Stough C, Teschke R et al. Phytother Res In Press
  9. Matthias A. et al. J Clin Pharm Ther 2007; 32: 233-239

Kava Quality Issues

Kava is derived from the rootstock of the sterile cultivated species of Piper methysticum. The psychosedative property of Kava has been attributed to the kavalactones, a group of structurally related lipophilic lactones. These compounds can represent 3 to 20% by weight of the dried rootstock, depending on the age of the plant and the specific cultivar. The majority of the Kava used commercially in the world is in the form of a high ethanol or other organic solvent extract, which extracts little more than the kavalactones and has reported potential hepatoxicity concerns. The Therapeutic Goods Administration (TGA) allows water extracted or plain unextracted root to be sold in Australia.

Traditionally Kava beverages are prepared by chewing or pounding the root to produce a cloudy, milky mash, which is then consumed orally. It is known that extraction with different solvents affects the phytochemical profile of the extract.

MediHerb investigated the difference in bioavailability of the water extract of Kava and the 96% ethanol extract using the Caco-2 monolayer in vitro model. The kavalactones (as kawain) were found to be potentially bioavailable as they all crossed the membrane quite readily with the exception of one kavalactone (yangonin). The water extract of Kava was only slightly less bioavailable than the ethanol extract. Therefore the clinical effect of the water extract of Kava would be similar to that of an ethanol extract.

Kawain % apical average data
Time water ethanol standard
10 11 11 12
20 21 22 23
30 30 31 33
60 59 59 61
90 80 81 84
120 87 89 91
150 92 95 97

Support

Additional Therapies

  • Combines well with Valerian Complex tablets to promote relaxation and encourage sleep.
  • Consider Nevaton or St John’s Wort 1.8g tablets to provide a tonic for the nervous system and ease the effects of occasional stress.
  • Combine with FemCo tablets to ease the effects of everyday tension and stress.
  • Consider Wild Yam Complex tablets to maintain feelings of general well-being/calm the nerves.
  • Consider Adrenal Complex tablets for adrenal support.
  • Consider HiPep tablets to reduce occasional stomach acid secretions.
  • Consider Nervagesic tablets to support relaxation in the nervous system and muscles. Δ