Standard Process Veterinary Formulas, Whole Food Supplements for Small Animal and Equine Patients.
Product Overview
Equine Mobility Support
You've probably seen many equine musculoskeletal injuries over the years. Everyday riding, training, and competitions produce friction and load-bearing stress on a horse's joints, ultimately affecting comfort and performance. Equine Mobility Support is a scientifically researched formula comprised of whole food ingredients that can help:
- Promote healthy joint function, flexibility, and mobility
- Support the repair of joints
- Supply antioxidants to help protect against free radical damage
These ingredients were carefully chosen, based on the latest research, for a horse's optimal joint health. Each ingredient provides specific nutritional support to every part of the musculoskeletal system.
Glucosamine
It is an important component of cartilage growth, maintenance, and repair. While research is ongoing in horses, meta-analysis of human clinical trials has confirmed the value of glucosamine in support of the osteoarthritic patient.1,2,3 In the horse, glucosamine has been implicated in regulation of matrix metalloproteinase expression, an important enzyme working in joint tissues.4,5 In practice, glucosamine is commonly used to support healthy joints, much the same way that glucosamine is used in humans.
Chondroitin Sulfate
It is an important component of the extracellular matrix of connective tissue. Low molecular weight chondroitin sulfate is bioavailable in the horse, although to a limited degree.6 While the mechanism of chondroitin sulfate action in joint health remains to be determined, it is an important component of compounds found in various functional components of the joint.
Wheat Germ Oil
It provides a rich source of vitamin E, which promotes healthy circulation, enhances athletic performance, and helps reduce muscle cramping. Vitamin E is an important lipophilic antioxidant implicated in a number of physiological functions. Tocopherols support immune function and lessen the inflammatory response by scavenging reactive oxygen species.
Flax Meal
It contains significant levels of omega-3 fatty acids, specifically alpha linolenic acid (ALA) and omega-3 fatty acids, which have been implicated in reducing inflammation. Studies have shown that omega-3 fatty acids reduced inflammatory thromboxane and decreased endotoxin-induced TNF production in horses.7,8
Ginger
It contains a broad spectrum of bioactive compounds. Several ginger compounds have well-documented effects on inflammation. For example, 6-gingerol and 6-paradol have both anti-inflammatory and anti-tumor (proliferation) activity, while 8-paradol and 9-shagaol have been shown to inhibit COX-2 activity. This action may explain ginger's historic use as an analgesic.9,10
Cinnamon
It is used to mask, in part, the spicy ginger taste, improving palatability. It also makes a great smelling product.
ACTIVE INGREDIENTS
PER ¼ CUP (33 g):
D-Glucosamine Sulfate 99%
(Shellfish Source)
4 g
Ginger Root
4 g
Chondroitin Sulfate 90%
(Bovine and Porcine)
1.6 g
OTHER INGREDIENTS: Cinnamon, flax meal, honey, and wheat germ oil.
SUGGESTED USE: ¼ cup (33 g)/1000# horse/day, or as directed.
WARNINGS: For equine use only. Do not administer to cattle or other ruminants. Keep all supplements out of the reach of children and other animals. In case of accidental overdose, contact a health care professional immediately.
PRECAUTIONS: Safe use in pregnant animals or animals for breeding has not been proven.
References
1 Clegg DO, Reda DJ, Harris CL, et. al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006; 354:795-808.
2 McAlindon TE, LaValley MP, Gulin JP, Felson DT. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA. 2000; 283:1469-1475.
3 Towheed TE, Maxwell L, Anastassiades TP, Shea B, Houpt J, Robinson V, Hochberg MC, Wells G. Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev: CD002946; 2005.
4 Neil KM, Orth MW, Coussens PM, Chan PS, Caron JP. Effects of glucosamine and chondroitin sulfate on mediators of osteoarthritis in cultured equine chondrocytes stimulated by use of recombinant equine interleukin-1beta. Am J Vet Res. 2005; 66:1861-1869.
5 Chan PS, Caron JP, Orth MW. Effect of glucosamine and chondroitin sulfate on regulation of gene expression of proteolytic enzymes and their inhibitors in interleukin-1-challenged bovine articular cartilage explants. Am J Vet Res. 2005; 66:1870-1876.
6 Du J, White N, Eddington ND. The bioavailability and pharmacokinetics of glucosamine hydrochloride and chondroitin sulfate after oral and intravenous single dose administration in the horse. Biopharm Drug Dispos. 2004; 25:109-116.
7 McCann ME, Moore JN, Carrick JB, Barton MH. Effect of intravenous infusion of omega-3 and omega-6 lipid emulsions on equine monocyte fatty acid composition and inflammatory mediator production in vitro. Shock. 2000; 14:222-228.
8 Morris DD, Henry MM, Moore JN, Fischer JK. Effect of dietary alpha-linolenic acid on endotoxin-induced production of tumor necrosis factor by peritoneal macrophages in horses. Am J Vet Res. 1991; 52:528-532.
9 Surh Y. Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances. Mutat Res. 1999; 428:305-327.
10 Tjendraputra E, Tran VH, Liu-Brennan D, Roufogalis BD, Duke CC. Effect of ginger constituents and synthetic analogues on cyclooxygenase-2 enzyme in intact cells. Bioorg Chem. 2001; 29:156-163.